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| Product Name | Recombinant Mouse BMP-4 (carrier-free) |
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| Description | Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the transforming growth factor beta (TGF-β) superfamily. BMPs play a key role in embryonic development, especially during heart, neural, and cartilage development. Around 20 BMP family members have been identified and characterized. BMPs signal through serine/threonine kinase receptors, composed of type I and II subtypes. Three type I receptors have been identified: type IA and IB BMP receptors and type IA activin receptors. Three type II receptors have also been recognized: type II BMP receptor and type II and IIB activin receptors. BMP-4 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and zebrafish. BMP-2 and BMP-4 are highly similar; they have 92% amino acid sequence identity. BMP-4 is required for mesoderm formation and patterning in mice, and BMP-4 KO mice are embryonic lethal. BMP-4 has an important role in postnatal tooth cytodifferentiation. Overexpression of BMP-4 has been associated with fibrodysplasia ossificans progressiva (FOP). |
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| Size | 2 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Bone morphogenetic protein 4 (BMP4), Bone morphogenetic protein 2B (BMP-2B) |
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| Gene, Accession, CAS # | Gene ID: 652 |
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| Catalog # | 595301 |
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| Order / More Info | Recombinant Mouse BMP-4 (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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