| 产品详情 |
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| Antigenic Specificity | PD-L1/CD274 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat (predicted: bovine) |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 100ug (sample available) |
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| Concentration | 500ug/ml. |
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| Applications | WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit IgG polyclonal antibody for Programmed cell death 1 ligand 1(CD274) detection. Tested with WB in Human;Mouse;Rat. No cross reactivity with other proteins. CD274(CD274 molecule), also known as PDCD1L1, PDL1, B7H1, CD274 molecule, cluster of differentiation(CD274) or B7 homolog 1(B7-H1), Programmed cell death 1 ligand 1, is a protein that in humans is encoded by the CD274 gene. Levels of B7H1 correlated with PTEN loss in glioblastoma specimens, and tumor-specific T cells lysed human glioma targets expressing wildtype PTEN more effectively than those expressing mutant PTEN. Sequence analysis predicted that it has 290-amino acid. immunoresistance in glioma is related to loss of the tumor suppressor PTEN and is mediated in part by B7H1.Programmed death ligand 1(PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. Using microarray analysis and flow cytometry, Barber et al.(2006) found that Pd1 was highly upregulated by functionally exhausted CD8 T cells from mice infected with a lymphocytic choriomeningitis virus(LCMV) strain causing chronic infection, but not by functional memory CD8 T cells from mice infected with an LCMV strain causing acute infection. |
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| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of human CD274(100-114aa QITDVKLQDAGVYRC), different from the related rat and mouse sequences by one amino acid. |
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| Other Names | Programmed cell death 1 ligand 1;PD-L1;PDCD1 ligand 1;Programmed death ligand 1;B7 homolog 1;B7-H1;CD274;CD274;B7H1, PDCD1L1, PDCD1LG1, PDL1; |
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| Gene, Accession # | CD274, UniProt: Q9NZQ7 |
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| Catalog # | PA1851 |
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| Price | |
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| Order / More Info | PD-L1/CD274 Antibody from BOSTER BIO |
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| Product Specific References | n/a |
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