产品名称 AML1 / RUNX1 Antibody from LIFESPAN BIOSCIENCES INC.
产品货号 LS-C501725
产品价格 现货询价,电话:010-67529703
产品规格 n/a
产品品牌 LIFESPAN BIOSCIENCES INC.
产品概述
产品详情
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Antigenic SpecificityAML1 / RUNX1
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formatbiotin conjugate
Sizen/a
Concentrationn/a
ApplicationsELISA
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DescriptionAML1 / RUNX1 Antibody (Biotin) LS-C501725. Specificity: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532).
ImmunogenRecombinant Human Runt-related transcription factor 1 protein (11-445AA)
Other NamesRUNX1, AMLCR1, Aml1 oncogene, AML1, AML1-EVI-1, CBF-alpha-2, CBFA2, Acute myeloid leukemia 1, EVI-1, PEBP2A2, PEA2-alpha B, AML1-EVI-1 fusion protein, Oncogene AML-1, PEBP2-alpha B, PEBP2aB
Gene, Accession #RUNX1, Gene ID: 861
Catalog #LS-C501725
Price
Order / More InfoAML1 / RUNX1 Antibody from LIFESPAN BIOSCIENCES INC.
Product Specific Referencesn/a
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