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| Product Name | Recombinant Human Galectin-3 (carrier-free) (E.coli expressed) |
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| Description | Galectin-3 is a member of the lectin family which includes 15 mammalian lectin members. Like all galectins, Galectin-3 contains a carbohydrate recognition binding domain of about 130 amino acids that enables the specific binding of β-galactosides. This protein has been shown to be involved in the cell adhesion, cell activation and chemoattraction, cell growth and differentiation, cell cycle, and apoptosis. Galectin-3 induces pro-inflammatory cytokines and inhibits Th2 type cytokine production. It chemoattracts monocytes and macrophages, and activates and degranulates basophils and mast cells. It was reported that Galectin-3 knock-out mice demonstrated reduced phagocytic properties in macrophages and Kupffer cells, indicating that this protein is involved in macrophage phagocytosis. Recently, Galectin-3 has been shown to be involved in cancer, inflammation, and fibrosis, heart disease, and stroke. It has also shown that the expression of galectin-3 is implicated in a variety of processes associated with heart failure, including myofibroblast proliferation, tissue repair, inflammation, fibrogenesis, and ventricular remodeling. In addition, Galectin-3 was found to contribute to the tumor cell evasion of the immune system. Galectin-3 is increasingly being used as a diagnostic marker for different cancers. It can be screened for and used as a prognostic factor to predict the progression of the cancer. Overexpression of Galectin-3 is associated with neoplastic transformation, enhancement of tumor cell adhesion to the extracellular matirx, and the subsequent metastatic spreading of the cancer cells. |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Lectin, Galactoside-Binding, Soluble, 3 (LGALS3), L31, GAL3, MAC2, Carbohydrate-Binding Protein 35 (CBP35), Galactose Binding Protein (GALBP), GALIG, Galactose-Specific Lectin 3 |
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| Gene, Accession, CAS # | Gene ID: 3958 |
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| Catalog # | 774408 |
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| Order / More Info | Recombinant Human Galectin-3 (carrier-free) (E.coli expressed) from BIOLEGEND |
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| Product Specific References | n/a |
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