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| Product Name | Recombinant Mouse CD27L (carrier-free) |
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| Description | CD27L is a 50 kD type II transmembrane glycoprotein and member of the tumor necrosis factor superfamily. Mouse CD27L and its human counterpart share about 56% amino acid sequence identity. The interaction between CD27L and CD27, a protein of the TNF receptor superfamily expressed on NK cells and subsets of T and B cells, provides costimulatory signals that are required for T cell proliferation, clonal expansion, and promotion of effector T cell formation. CD27L-CD27 interaction on mouse B cells on the other hand, has been shown to inhibit terminal differentiation of B cells into plasma cells. CD27L expression is induced by antigen receptor activation in B cells and at low levels in mouse T cells. CD27 interaction with recombinant soluble CD27L protein (sCD27L), has shown that sCD27L enhances IFN-γ secretion by CD56(bright) NK cells in the presence of IL-12, and these NK cells were able to suppress HCV replication. Also, CD8+ T cells stimulated with sCD27L in the presence of Ag showed enhanced proliferation and production of IL-2 and IFN-γ in vitro. In addition, administration of Ag and soluble CD27L induces expansion of Ag-specific CD8+ T cells in vivo. Data suggests that sCD27L is a potent stimulator of antiglioma immune responses that depend on CD8+ T cells; therefore, sCD27L might be an adjuvant for future immunotherapy trials for glioblastoma. |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | CD27 ligand, CD70, Ki-24 antigen, TNFSF7 |
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| Gene, Accession, CAS # | Gene ID: 21948 |
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| Catalog # | 550406 |
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| Order / More Info | Recombinant Mouse CD27L (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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