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| Product Name | Recombinant Mouse CD30L (carrier-free) |
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| Description | CD30L is a type II membrane glycoprotein belonging to the TNFL superfamily, which includes CD27L (CD70), FasL (CD95L), OX40L (CD134L), 4-1BB ligand (CD137L), and CD40L (CD154). CD30 is a member of the TNF receptor superfamily, and it was originally identified as the cell surface antigen Ki-1, on Hodgkin and Reed-Sternberg cells. Recombinant murine CD30L shares functional properties with CD40L in the regulation of murine B cell growth and differentiation in vitro. CD30L stimulates B cell proliferation, antigen-specific antibody production, and polyclonal immunoglobulin secretion in a cytokine-dependent manner. IL-4 and IL-5 are required for B cell proliferation and IL-2 and IL-5 for antigen-specific immunoglobulin production. Interaction of CD30L, expressed in human B cells, with CD30+ T cells inhibits class switching and antibody production in human IgD+, IgM+ B cells. Cross-linking of CD30 ligand by a monoclonal antibody or by CD30-Fc fusion protein induces production of IL-8 from freshly isolated human neutrophils. The signaling induced from the receptor to the cell expressing the transmembrane protein is known as reverse signaling. CD30L/CD30 signaling seems to be involved in Th1 and Th2 cell responses and plays a key role in Th17 differentiation in mice. Mast cells are the predominant CD30L-positive cell in chronic inflammatory skin diseases such as psoriasis and atopic dermatitis. CD30 and CD30L expression is upregulated in lesional skin in these conditions. |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Tumor necrosis factor ligand superfamily member 8 (TNFSF8), CD153, CD30LG |
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| Gene, Accession, CAS # | Gene ID: 21949 |
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| Catalog # | 553604 |
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| Order / More Info | Recombinant Mouse CD30L (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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