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产品名称 Neurofilament H & M (NF-H/NF-M), Phospho Antibody from BIOLEGEND
产品货号 835613
产品价格 现货询价，电话：010-67529703
产品规格 25 µg
产品品牌 BIOLEGEND
产品概述
产品详情
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Antigenic SpecificityNeurofilament H & M (NF-H/NF-M), Phospho
CloneSMI 35
Host SpeciesMouse
Reactive Specieshuman, mouse, rat
IsotypeIgG1, κ
FormatAlexa Fluor® 488 conjugate
Size25 µg
Concentrationn/a
ApplicationsIHC-P
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DescriptionAlexa Fluor® 488 anti-Neurofilament H & M (NF-H/NF-M), Hypophosphorylated. Neurofilaments (NFs) are approximately 10 nanometer intermediate filaments found in neurons. They are a major component of the neuronal cytoskeleton, and function primarily to provide structural support for the axon and to regulate the axon diameter. There are three major NF subunits, and the names given to these subunits are based upon the apparent molecular mass of the mammalian subunits on SDS-PAGE. The light or lowest neurofilament (NF-L) runs at 68-70 kD. The medium or middle (NF-M) runs at about 145-160 kD, and the heavy or highest (NF-H) runs at 200-220 kD. However, the actual molecular weight of these proteins is considerably lower due to the highly charged C-terminal regions of the molecules. The level of NF gene expression correlates with the axonal diameter, which controls how fast electrical signals travel down the axon. Mutant mice with NF abnormalities have phenotypes resembling amyotrophic lateral sclerosis. NF immunostaining is common in diagnostic neuropathology. It is useful for differentiating neurons (positive for NF) from the glia (negative for NF).
Immunogenn/a
Other NamesNeurofilament heavy polypeptide, NF-H, 200 kD neurofilament protein, neurofilament triplet H protein
Gene, Accession #Gene ID: 4744
Catalog #835613
Price
Order / More InfoNeurofilament H & M (NF-H/NF-M), Phospho Antibody from BIOLEGEND
Product Specific Referencesn/a
产品资料