| 产品详情 |
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| Antigenic Specificity | Sequestosome 1 (SQSTM1) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 200 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Sequestosome 1 (SQSTM1, p62) is a ubiquitin binding protein involved in cell signaling, oxidative stress, and autophagy. It was first identified as a protein that binds to the SH2 domain of p56Lck , and independently found to interact with PKCzeta. SQSTM1 was subsequently found to interact with ubiquitin, providing a scaffold for several signaling proteins and triggering degradation of proteins through the proteasome or lysosome. Interaction between SQSTM1 and TRAF6 leads to the K63-linked polyubiquitination of TRAF6 and subsequent activation of the NF-kappaB pathway. Protein aggregates formed by SQSTM1 can be degraded by the autophagosome. SQSTM1 binds autophagosomal membrane protein LC3/Atg8, bringing SQSTM1-containing protein aggregates to the autophagosome. Lysosomal degradation of autophagosomes leads to a decrease in SQSTM1 levels during autophagy, conversely, autophagy inhibitors stabilize SQSTM1 levels. Studies have demonstrated a link between SQSTM1 and oxidative stress. SQSTM1 interacts with KEAP1, which is a cytoplasmic inhibitor of NRF2, a key transcription factor involved in cellular responses to oxidative stress. Thus, accumulation of SQSTM1 can lead to an increase in NRF2 activity.Synonyms: SQSTM1, A170, OSIL, PDB3, ZIP3, p60, p62, p62B |
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| Immunogen | Recombinant protein of human SQSTM1 |
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| Other Names | SQSTM1|sqstm1|MGC79491|A170|OSIL|PDB3|ZIP3|p60|p62|p62B|OSF-6|Osi|STAP|ZIP|sb:cb621|zgc:85784 |
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| Gene, Accession # | Gene ID: 8878,18412,113894 |
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| Catalog # | ABIN1514709 |
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| Price | |
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| Order / More Info | Sequestosome 1 (SQSTM1) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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