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| Product Name | HLA-DOB, 27-224aa, Human, His tag, E.coli (Denatured) |
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| Description | Purity: > 95% by SDS - PAGE Format: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol . HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Recombinant human HLA-DOB protein, fused to His-tag at N-terminus, was expressed in E.coli. |
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| Size | 0.5mg, 100ug, 20ug |
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| Concentration | n/a |
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| Applications | SDS-PAGE |
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| Other Names | Major histocompatibility complex class II DO beta, Major histocompatibility complex, class II, DO beta, DOB |
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| Gene, Accession, CAS # | NP 002111 |
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| Catalog # | ATGP2683 |
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| Order / More Info | HLA-DOB, 27-224aa, Human, His tag, E.coli (Denatured) from ATGen |
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| Product Specific References | n/a |
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