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| Product Name | Recombinant Mouse Podoplanin-Fc Chimera (carrier-free) |
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| Description | Podoplanin, also termed GP38, is a 38 kD type I transmembrane sialoglycoprotein and a member of the podoplanin family. Mouse and human GP38 share 46% amino acid sequence homology. Alternative splicing transcripts, encoding different isoforms of GP38, have been identified. Structurally, GP38 has a 119 amino acid extracellular domain (ECD), a 21 amino acid transmembrane region, and a 10 amino acid cytoplasmic tail. This type I protein is heavily O-glycosylated and has a diverse distribution in human tissues, including glomerular epithelial cells, lung alveolar cells, lymphatic endothelial cells, and neural tissues. GP38 is also expressed by tumor cells such as testicular seminomas, squamous cell carcinomas, colorectal tumors, and brain tumors. Therefore, this protein is a target of antibody therapy in cancer treatment. GP38 induces platelet aggregation and tumor metastasis through its association with CLEC2. The binding of GP38 and CLEC2 is important for maintaining high endothelial cell venule integrity. Also, GP38 is necessary for lymphatic vessel formation, normal lung cell proliferation, and alveolus formation at birth. In addition, GP38 was shown to be a novel marker for immature hepatic progenitor cells in fetal livers. GP38 is upregulated in Th17 cells in the arthritic joints in SKG mice, suggesting that this protein could be a useful Th17 cell marker for diagnosing pathological conditions of autoimmune diseases, including rheumatoid arthritis. |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Glycoprotein 38 (Gp38), T1 alpha (T1a), Podoplanin, OTS-8, RANDAM-2, Transmembrane glycoprotein E11 |
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| Gene, Accession, CAS # | Gene ID: 14726 |
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| Catalog # | 551704 |
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| Order / More Info | Recombinant Mouse Podoplanin-Fc Chimera (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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