产品名称 Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1) (C-Term) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN350862
产品价格 现货询价,电话:010-67529703
产品规格 100 µL
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
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Antigenic SpecificitySortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1) (C-Term)
Clonepolyclonal
Host SpeciesRabbit
Reactive Speciesmouse
Isotypen/a
Formatserum
Size100 µL
Concentrationn/a
ApplicationsImmunohistochemistry (IHC),Western Blotting (WB)
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DescriptionFunction: Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. May play a role in neural organization, as well as the establishment of embryonic organ systems.Subcellular location: Membrane, Single-pass type I membrane protein.Tissue specificity: Abundant in brain, where it is mainly expressed in adult cerebellum, hippocampal ca regions, dentate gyrus, and to a much lesser extent in the cerebral cortex. Detectable in kidney, skeletal muscle, lung and spleen, but not in the liver.Developmental stage: Expressed as early as embryonic day 6.5 (E6.5) and peaks at E11, the main location is in the CNS during development. At early stages, it is abundant in a subpopulation of neurons in the cerebral cortex, in the hippocampus, and granular and Purkinje cell layers in the cerebellum, whereas in the adult, expression in cerebellar granular cells and in the cerebral cortex is low. Expression occurs also in a variety of glands and organs during organogenesis. Also known as: Sortilin-related receptor, Sortilin related receptor, Sorting protein related receptor containing LDLR class A repeats, mSorLA, SorLA-1, Low density lipoprotein receptor relative with 11 ligand-binding repeats, LDLR relative with 11 ligand binding repeats, LR11, Gp250, SORL.
ImmunogenA synthetic peptide from c-terminal of mouse SorLA (Sortilin related receptor, Sorting protein related receptor containing) conjugated to an immunogenic carrier protein was used as the immunogen.
Other NamesSORL1|C11orf32|LR11|LRP9|SORLA|SorLA-1|gp250|SorLA|2900010L19Rik|AI596264|AW261561|mSorLA|Lr11|RGD619914
Gene, Accession #Gene ID: 20660
Catalog #ABIN350862
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Order / More InfoSortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1) (C-Term) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific ReferencesPubMed: 9510025, 9726247
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