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| Product Name | Active Recombinant Human BAFF |
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| Description | Human recombinant protein expressed in Nicotiana benthamiana. It is produced by transient expression in non-transgenic plants. This product contains no animal-derived components or impurities. Animal Free product. BAFF (B lymphocyte activating factor) is a member of the tumour necrosis factor (TNF) ligand family which is expressed in T Cells, macrophages, monocytes and dendritic cells. It is also known as BLyS, THANK, TALL, zTNF4 and TNFS20. BAFF enhances B cell survival in vitro and has emerged as a key regulator of periphery B cell and it is vital homeostatic cytokine for B cells that helps regulate both innate and adaptive immune responses. BAFF binds to three TNF receptors: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium modulator and cyclophilin ligand interactor(TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF 13C).The human BAFF gene code for a 285 amino acids type II transmembrane protein. Recombinant human soluble BAFF is a 151 amino acids containing the TNF-like portion of the extracellular domain of BAFF. Recombinant human BAFF is a glycosylated polypeptide chain containing 151 amino acids (134-285 aa Q9Y275 (TN13B_HUMAN) fused to 10 His tag at N-terminal. rHuman BAFF has a molecular mass between 18 and 20kDa. Purity >97% by SDS-PAGE gel |
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| Size | 1 µg, 5 µg, 10 µg, 20 µg, 50 µg, 100µg, 250µg |
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| Concentration | n/a |
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| Applications | Functional studies, Cell culture, Western Blot. |
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| Other Names | B lymphocyte stimulator; BLyS; B-cell-activating factor |
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| Gene, Accession, CAS # | UniProt: Q9Y275 |
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| Catalog # | RF0030 |
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| Order / More Info | Active Recombinant Human BAFF from AGRENVEC |
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| Product Specific References | -Schneider, P., et al. (1999). BAAF, a Novel Ligand of the Tumour Necrosis Factor Family, Stimulates B cell Growth. J. Exp. Med, 189:1747-1754. -Mackay, J.L. and Browning. (2002). BAFF: a fundamental survival factor for B cells. Nat. Rev. Immunol. 2:465-475. -Harless Smith, S., et al. (2003). Integrating B cell homeostasis and selection with BAFF. Arch. Immunol. There. Exp. 51:209-218. -Wu, T. H., et al. (2009). Expression, Characterization of recombinant human Soluble Baff Secreted from CHO Cell. Molecular Biology. 43: 76-81. |
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