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| Product Name | Active Recombinant Human Interleukin-10 |
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| Description | Human recombinant protein expressed in Nicotiana benthamiana. It is produced by transient expression in non-transgenic plants. This product contains no animal-derived components or impurities. Animal Free product. Interleukin 10 (IL-10) is an anti-inflammatory cytokine initially characterized as a T helper (TH)2 specific cytokine, however, further investigations revealed that IL- 10 production was also associated with T regulatory cell responses. It is now known that almost all cells of both the innate and adaptive arms of the immune system can express IL-10, including dendritic cells (DC), macrophages, mast cells, natural killer cells (NK), eosinophil's, neutrophils, B cells, CD8C T cells, and TH1, TH2, and TH17 CD4C T cells IL-10 functions by inhibiting pro-inflammatory cytokines made by macrophages and regulatory T cells including, IFN-gamma, TNF-alpha, IL-2, and IL-3, IL-4, and GM-CSF. IL-10 is also known to suppress antigen presentation on antigen presenting cells. It also stimulates the growth of mast cells, is a cytotoxic T cell differentiation factor, and stimulates B cell differentiation. Recombinant human IL-10 is a glycosylated, non-disulphide linked homodimer with an apparent molecular mass of 17 kDa due to glycosylation. Glycosylation contributes to stability in cell growth media and other applications. Purity >97% by SDS-PAGE gel |
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| Size | 1 µg, 10 µg, 100 µg, 250 µg |
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| Concentration | n/a |
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| Applications | Functional studies, Cell culture, Western Blot |
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| Other Names | Cytokine synthesis inhibitory factor/ CSIF. |
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| Gene, Accession, CAS # | UniProt: P22301 |
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| Catalog # | RF0103 |
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| Order / More Info | Active Recombinant Human Interleukin-10 from AGRENVEC |
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| Product Specific References | - O Garra, A. and P. Vieir, 2004. Regulatory T cells and mechanisms of immune system control. Nat.Med., 10, 801-805. - Maloy, K. J. and F. Powrie, 2001. Regulatory T cells in the control of immune pathology. Nat. Immunol., 2, 816-822. - Fillatreau, S., et al; 2002. B cells regulate autoimmunity by provision of IL- 10. Nat. Immunol., 3, 944-950. - Maynard, C.L. and C.T. Weaver, 2008. Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation. Immunol.Rev. 226, 219-233. - Mauri, C. and A. Bosma, 2012. Immune regulatory function of B cells. Annu. Rev. Immunol., 30, 221-241. |
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