产品名称 LGR5 Antibody from ALDEVRON FREIBURG GmbH
产品货号 GM-0607
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 ALDEVRON FREIBURG GmbH
产品概述
产品详情
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Antigenic SpecificityLGR5
CloneBEE-6F7
Host SpeciesRat
Reactive Specieshuman
IsotypeIgG2a/kappa
Formatpurified
Size100 µg
Concentrationn/a
Applicationsflow cytometry, CELISA
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DescriptionLGR5 (Leucine-rich repeat- containing G protein-coupled receptor 5), also known as GPR49. belongs to the superfamily of G protein-coupled receptors (GPCRs). It is a 907 amino acid multi-pass membrane protein and has multiple N-terminal leucine-rich repeats, which are important for interaction with the glycoprotein ligands, and 7 transmembrane domains. LGR5 is expressed across a diverse range of tissue such as in the muscle, placenta, spinal cord and brain and particularly as a biomarker of adult stem cells in certain tissues. LGR5 is a member of the Wnt signaling pathway. Although its ligand remains elusive, it has been shown that costimulation with R-spondin 1 and Wnt-3a induce increased internalization of LGR5. LGR5 is overexpressed in certain cancer types, e.g. gastrointestinal tumours and is thought to represent a tumour suppressor, although its role there is still unclear.
ImmunogencDNA
Other Namesn/a
Gene, Accession #n/a
Catalog #GM-0607
Price
Order / More InfoLGR5 Antibody from ALDEVRON FREIBURG GmbH
Product Specific Referencesn/a
产品资料