| 产品详情 |
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| Antigenic Specificity | APP |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG2b, k |
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| Format | purified |
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| Size | 100ul, 50ul |
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| Concentration | n/a |
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| Applications | ELISA, WB, Flow cytometry, ICC/IF |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Amyloid precursor protein (APP) is the precursor molecule whose proteolysis generates amyloid beta (AB), a 39- to 42- amino acid peptide and this amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's diseases patients. APP is an integral membrane protein that is phosphorylated in the cytoplasmic and extracellular domains. It has been reported that cell-surface APP plays a role in neurite extension of primary cultured hippocampal neurons. The large extracellular domain of APP is also reported to bind extracellular matrix molecules such as heparin, laminin, and collagen, which can mediate cell adhesion and neurite outgrowth. Abnormal regulation of the metabolism of APP may contribute to the deposition of plaques. |
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| Immunogen | Recombinant human APP (18-289aa) purified from E. coli |
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| Other Names | amyloid beta A4 protein precursor, isoform , amyloid beta (A4) precursor protein, Alzheimer disease, peptidase nexin-II |
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| Gene, Accession # | NP 000475 |
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| Catalog # | AAP0836 |
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| Price | |
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| Order / More Info | APP Antibody from ATGen |
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| Product Specific References | n/a |
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