产品名称 Activin A Antibody from BIOLEGEND
产品货号 693603
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 BIOLEGEND
产品概述
产品详情
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Antigenic SpecificityActivin A
CloneA15095A
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG2b, κ
Formatpurified, azide-free
Size100 µg
Concentrationn/a
ApplicationsNeut
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DescriptionUltra-LEAF™ Purified anti-Activin A. Activin A was initially identified in ovarian fluid as a stimulator of FSH secretion from anterior pituitary cells. Activin A is a member of the TGFb1 family which includes TGFs, Activins, Nodal, growth and differentiation factors (GDF), and bone morphogenetic proteins (BMPs). Activin A is a dimer of the beta A subunits of human inhibin; the beta A subunit binds the beta B subunit of inhibin to form Activin AB. The beta B subunit also exists as a heterodimer to form Activin B. Activin A binds two type I and two type II serine/threonine kinase receptors at the same time. The type II receptor kinase is constitutively active and phosphorylates the type I receptor after the formation of the ligand-receptor complex. Five type II receptors have been identified: ActRIIA, ActRIIB, BMPRII, TGFβRII, and MISRII. ActRIIB binds to Activin A, BMP-2, BMP-7, GDF-8, and GDF-11. The type I receptors are named activin receptor-like kinases 1 to 7 (ALK1~7), and Activins bind to ALK4 and ALK7. Follistatin (FS) is a natural Activin A antagonist; FS neutralizes its biologic activities by preventing Activin A interaction with its receptors. Activin A has pleiotropic functions. It is a morphogen during embryonal development, regulating chondrogenic and osteogenic differentiation of mesenchymal progenitor cells (MPC). Activin A has been associated with neuroprotection, apoptosis, and fibrosis. Also, high levels of Activin A have been found in synovial fluid from patients with rheumatoid arthritis, inflammatory bowel disease, and gout. In addition, it has been speculated that Activin A, in collaboration with TGFb1 and IL-25, promotes TH9 generation and the development of allergic pathology.
ImmunogenRecombinant human Activin A.
Other NamesInhibin BA (INHBA), Inhibin B-1, Follicule stimulating hormone-releasing protein (FRP), FSH releasing protein, FSH releasing factor, Erythroid differentiation factor (EDF)
Gene, Accession #Gene ID: 3624
Catalog #693603
Price
Order / More InfoActivin A Antibody from BIOLEGEND
Product Specific Referencesn/a
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