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| Product Name | Recombinant Human CD326/EPCAM (carrier-free) |
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| Description | EPCAM is a type I transmembrane protein, composed of thyroglobulin type I domain on the extracellular domain, a transmembrane region and a 26-amino acid intracellular region. EPCAM is expressed in epithelial tissues, but it cannot be detected in normal squamous epithelia except carcinoma. In mice, the homolog of human EPCAM has been found in thymic epithelial cells, thymocytes, T cells and dendritic cells. The expression level of EPCAM differs among tissues, but it is higher in proliferating cells than in differentiated cells. Several studies demonstrated that EPCAM is involved in cell adhesion, proliferation, migration and gene expression. EPCAM mediates homophilic cell-cell adhesions in Ca2+-independent manner. Its N-terminal domain is necessary for adhesion. In addition, EPCAM serves as a diagnostic biomarker of cancer. High level of EPCAM is found in several carcinoma and correlates with tumor progression in cervical neoplasia and survival in breast cancer patients. EPCAM associates with the tight junction protein claudin 7, resulting in tumor growth, metastasis formation and apoptotic resistance. EPCAM undergoes intramembrane proteolysis, catalyzed by TNF-α converting enzyme (TACE) and presenilin-2 (PS-2/γ-secretase), which in turn produces the extracellular (EpEX) and intracellular (EpICD) domains of EPCAM. EpICD forms a nuclear complex with β-catenin, its co-activator FHL2 and Lef-1. It has been indicated that EPCAM upregulates oncogenic transcriptional factor c-myc and cell cycle-related proteins Cyclin A/E. Furthermore, EPCAM can induce expression of reprogramming factors, including OCT4, SOX2 and NANOG. EPCAM is a potential target in cancer therapy. Antibodies against EPCAM and vaccine-based clinical trials in different carcinoma have been conducted. |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Cluster of differentiation 326, CD326, Epithelial cell adhesion molecule, Ep-CAM, Adenocarcinoma-associated antigen, Cell surface glycoprotein Trop-1, TROP1, Epithelial glycoprotein, EGP, Epithelial glycoprotein 314, EGP314, KS 1/4 antigen, KSA, Major gastrointestinal tumor-associated protein GA733-2, Tumor-associated calcium signal transducer 1, M1S2, M4S1, MIC18, TACSTD1 |
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| Gene, Accession, CAS # | Gene ID: 4072 |
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| Catalog # | 777306 |
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| Order / More Info | Recombinant Human CD326/EPCAM (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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