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| Product Name | Recombinant Human CD112-Fc Chimera (carrier-free) |
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| Description | CD112/Nectin-2, also known as poliovirus receptor related protein 2 (PVRL2), is a Ca2+ independent immunoglobulin-like cell adhesion molecule that belongs to Nectin family. Nectins were originally identified as virus receptors and the family consists of four members, nectin-1, nectin-2 , nectin-3 and nectin-4. Nectins-1, nectin-2, and nectin-3 were named PVRL1, PVRL2, and PVRL3 and assigned as CD111, CD112, and CD113, respectively. Nectins mediate both homophilic and heterophilic interactions. They first form cis-homodimers followed by dimer formation in trans. The trans-interaction can be either homophilic or heterophilic. CD112/Nectin-2 also binds to DNAM-1/CD226 on NK cells. The interaction between CD112 and CD226 can induce NK cell and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112/Nectin-2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus. CD112/Nectin-2 localizes to adherens junctions between neurons, endothelial cells, epithelial cells, and fibroblasts. |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Poliovirus receptor-like 2, PVRL2, Herpesvirus entry mediator B, HVEB, Poliovirus receptor-related 2, PRR2, CD112 antigen, Nectin2, Nectin-2 |
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| Gene, Accession, CAS # | Gene ID: 5819 |
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| Catalog # | 772006 |
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| Order / More Info | Recombinant Human CD112-Fc Chimera (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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