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| Product Name | Recombinant Human CD23/FCER2 (carrier-free) |
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| Description | CD23 is a 45 kD type II transmembrane glycoprotein that is a member of the subgroup of the C-type lectin superfamily. CD23 is a low affinity receptor for IgE, CR2/CD21, CD11b, and CD11c. CD23 is expressed by a wide variety of cell types and has essential function in the regulation of IgE production and in the differentiation of B cells. Soluble CD23 induces IgE secretion by binding to CD21. On the other hand, secreted IgE will bind CD23 on B-cell membranes, preventing its cleavage, and thus shutting down further IgE production. In human monocytes, CD23 interaction with CD11b and CD11c results in the release of pro-inflammatory cytokines. CD23 can be proteolytically cleaved to generate soluble CD23 fragments of various molecular weights. Both soluble and membrane bound CD23 show bioactivity. |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | FCER2, Leu-20, FcεRII, IgE Fc receptor, BLAST-2, B6, Immunoglobulin E-binding factor, IGEBF, C-type lectin domain family 4 member J, CLEC4J, low affinity IgE receptor, Low affinity immunoglobulin epsilon Fc receptor, Lymphocyte IgE receptor |
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| Gene, Accession, CAS # | Gene ID: 2208 |
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| Catalog # | 782504 |
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| Order / More Info | Recombinant Human CD23/FCER2 (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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