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| Product Name | Active Caspase-1, rat recombinant |
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| Description | Caspase-1 (also known as ICE) is a prototypical member of the caspase-family of cysteine proteases. Caspase-1 exists in cells as an inactive 45 kDa proenzyme. The pro-enzyme is matured by proteolysis to yield large (20 kDa) and small (10 kDa) subunits. The active caspase-1 is a heterotetramer consisting of two large and two small subunits. To date the regulatory mechanism of caspase-1 activation and the role of caspase-1 in apoptosis are poorly understood. In THP-1 cells, a large proportion of the caspase-1 is present in the inactive proenzyme form. The recombinant rat caspase-1 was expressed in E. coli as a single polypeptide of 284 amino acids with molecular weight of 34.6. The caspase-1 is purified and activated by proprietary techniques |
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| Size | 25 units |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, IL-1BC, p45. |
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| Gene, Accession, CAS # | Casp1, Accession: P43527 |
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| Catalog # | 7524-25 |
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| Order / More Info | Active Caspase-1, rat recombinant from BIOVISION, INC. |
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| Product Specific References | n/a |
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