| 产品详情 |
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| Product Name | A317491 |
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| Description | Purity ~99% (HPLC). A potent, selective, and competitive non-nucleotide antagonist of P2X3 and P2X2/3 receptors that blocks receptor-mediated Ca2+ flux (Ki = 22 and 92nM for rat P2X3 and P2X2/3 receptor and 22 and 9nM for human P2X3 and P2X2/3 receptor, respectively). Its R-enantiomer has significantly reduced activity at these receptors. Exhibits high selectivity over other purinergic receptors. Shown to reduce thermal and mechanical hyperalgesia in rat models (ED50 = 10-15uM/kg, s.c). Its anti-nociceptive effects have a rapid on-set and persist for up to 5 hours after sub-cutaneous administration. Also shown to block dorsal root ganglion currents in a dose-dependent manner (IC50 = 15nM). Solubility: H2O Primary Target: P2X3 Primary Target Ki: 22nM |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | A317491 ((S)-5-((3-phenoxybenzyl)(1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)benzene-1,2,4-tricarboxylic Acid, P2X3 Purinergic Receptors Antagonist, A317491, P2X2/3 Purinergic Receptors Antagonist, A317491, A 317491) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217136 |
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| Order / More Info | A317491 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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