| 产品详情 |
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| Product Name | RGB-286638, free base |
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| Description | RGB-286638 is a potent and selective cyclin-dependent kinase (CDK) inhibitor with IC50 values of 1, 2, 3 and 44 nM for CDK9, CDK1, CDK2, and CDK4, respectively. Less potent against cyclin H-CDK7 and cyclin D3-CDK6. It inhibits cell cycle progression in cancer cells by targeting CDKs, and is also found to induce apoptosis. In a range of pre-clinical models of solid and hematological tumors, RGB-286638 treatment results in tumor regression and increased survival. MW: 545.63. Purity ≥98% by HPLC |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-[3-[4-[[4-(2-methoxyethyl)piperazin-1-yl]methyl]phenyl]-4-oxo-1H-indeno[1,2-c]pyrazol-5-yl]-3-morpholin-4-ylurea |
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| Gene, Accession, CAS # | CAS: 784210-88-4 |
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| Catalog # | 2886-25 |
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| Price | |
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| Order / More Info | RGB-286638, free base from BIOVISION, INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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