| 产品详情 |
| Edit |   |
|---|
| Product Name | Recombinant Human FGF-4 (Animal-Free) |
|---|
| Description | FGF-4 was first identified as HST-1 gene by a NIH3T3 transforming assay. It belongs to the FGF family that includes 22 members, FGF-1 through FGF-23. FGF-15 has not been identified in humans. FGF-4 exhibits strong effects on many cell types and tissues and plays an important role in both embryogenesis and adult tissue stem cell development in a variety of organisms. FGF-4 can stimulate limb mesenchyme proliferation and can provide all the signals required for normal outgrowth and patterning of the limb. FGF-4 mRNA has been detected in the apical ectodermal ridge of the limb bud in day 11 and 12 embryos. FGF-4 is also involved in early heart development by supporting the proliferation and differentiation of precardiac myoblasts. In adults, FGF-4 is expressed in the testis and its overexpression results in enhanced spermatogenesis. FGF-4 is also a potent inducer of platelet production from megakaryocytes. FGF-4 expression has been detected in the brain at both neonatal and adult stages. FGF-4 can induce neural stem cell proliferation and neuronal differentiation. The diverse functions of FGF-4 are mediated by FGF receptors (FGFR) that contain an extracellular ligand-binding domain with three immunoglobulin-like domains. Like other FGFs, FGF-4 also binds to anionic glycosaminoglycans heparin and heparin sulfate with high affinity. Heparin sulfate availability has been shown to regulate the binding between FGF-4 and its receptors. The role of FGF-4 in cancer has also been extensively investigated. FGF-4 is an angiogenic protein, and amplification of FGF-4 gene has been found in many human tumors. It has been shown that FGF-4 is a potential target for the treatment of human testicular tumors. |
|---|
| Size | 25 µg |
|---|
| Concentration | n/a |
|---|
| Applications | BA |
|---|
| Other Names | Fibroslast Growth Factor 4, FGF4, Heparin-Binding Growth Factor 4, HSTF1, HBGF-4, HBGF4, HST-1, HST1, K-FGF, KFGF, KS3, Kaposi Sacrcoma Oncogene, Heparin Secretory Transforming Protein 1 |
|---|
| Gene, Accession, CAS # | Gene ID: 2249 |
|---|
| Catalog # | 710404 |
|---|
| Price | |
|---|
| Order / More Info | Recombinant Human FGF-4 (Animal-Free) from BIOLEGEND |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|