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| Product Name | Anti-IA2 ELISA |
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| Description | Anti-IA2 ELISA Assay Kit is an enzyme immunoassay for the quantitative determination of autoantibodies to Protein Tyrosine Phosphatase (IA2 Abs) in human serum. Anti-IA2 ELISA Assay Kit uses the ability of IA2 Abs acting divalently and forming a bridge between immobilized IA2 and liquid-phase IA2-Biotin. In the first step IA2 Ab from the sample bind to IA2 coated on the microtiter plate. In a second step IA2-Biotin binds to this complex. The bound IA2-Biotin correlates with the amount of IA2 Abs in patient's serum. Unbound IA2-Biotin is removed by washing. The bound IA2-Biotin could be quantified by addition of Streptavidin- peroxidase and a colorogenic substrate (TMB) and reading the optical density (OD) at 450 nm. Sample Types: serum. Range: 15 - 400 IU/ml. Sensitivity: 0.5 IU/ml. Time: overnight • IA2, a member of the protein tyrosine phosphatases family is localized in the dense granules of pancreatic beta cells and the second defined recombinant islet cell Antigens. IA2 shares sequence identity with the islet cell Antigens 512. The higher frequency of antibodies to IA2 is explained by the presence of autoantibodies directed to the COOH terminus of IA2 which is lacking in the ICA512 molecule. IA2 autoantibodies are present in the majority of individuals with new-onset type 1 diabetes and in individuals in the pre-diabetic phase of the disease. The appearance of autoantibodies to IA2 seems to be correlated with the rapid progression to overt type 1 diabetes. |
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| Size | 1 x 96 well |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | IA2, Protein Tyrosine Phosphatase like protein |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | IA231-K01 |
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| Order / More Info | Anti-IA2 ELISA from EAGLE BIOSCIENCES INC. |
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| Product Specific References | n/a |
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