| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | CD46, Human |
|---|
| Clone | M177 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG1 |
|---|
| Format | fluorescein (FITC) conjugate |
|---|
| Size | 100 µg |
|---|
| Concentration | 100 µg/ml |
|---|
| Applications | frozen sections, FC, functional studies, immunoassay, IP, WB |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | The monoclonal antibody M177 recognizes CD46, also designated membrane cofactor protein (MCP). CD46 is a 45-70 kDa protein with genetic and tissue-specific heterogeneity.- It is expressed on every cell and tissue, with the exception of erythrocytes. CD46 serves to inhibit complement activation on host tissue. It performs this function by serving as a cofactor which binds to C3b and C4b. This binding is permitted by factor I, a serine protease of plasma, to degrade C3b and C4b and serves to protect the host cell against autologous attack. It also serves as a receptor for measles virus. Four isoforms of CD46 predominate and arise by alternative splicing of a single CD46 gene. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR)). The monoclonal antibody M177 reacts with the SCR2 domain. |
|---|
| Immunogen | Purified MCP |
|---|
| Other Names | Membrane cofactor protein, TLX, trophoblast leucocyte common antigen. |
|---|
| Gene, Accession # | CD46 |
|---|
| Catalog # | HM2103F |
|---|
| Price | |
|---|
| Order / More Info | CD46, Human Antibody from HYCULT BIOTECH |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|