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| Antigenic Specificity | Coagulation factor VII, Human |
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| Clone | VII-1 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | unconjugated |
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| Size | 100 µg |
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| Concentration | 100 µg/ml |
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| Applications | WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Antibody clone CLB VII-1 recognizes human coagulation factor VII. FVII is a serine protease-coagulating element responsible for the initiation of an extrinsic pathway of coagulation. FVII is vitamin K dependent and is synthesized by hepatocytes. It is a single chain glycoprotein of ca 50kDa, consisting of 408 amino acids. The protein has several functional domains, a gamma-carboxyglutamic acid-rich domain at the N-terminus, 2 EGF-like domains and the C-terminal serine protease domain. FVII itself has no real activity. Activation of FVII leads to FVIIa. At the site of injury, blood clotting starts by interaction of FVII with tissue factor (TF). Complexed with Ca2+, FVIIa/TF activates FIX and FX, which ultimately leads to the formation of a fibrin clot. FVII deficiency is a rare haemological disorder with an incidence of 1/500000. Disease is characterized by multiple clinical phenotypes, from asymptomatic to life threatening bleedings. FVII levels can be measured by ELISA of turbidimetry, although plasma levels are low (0.5µg/ml). Plasma levels can be influenced by gene polymorphisms. |
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| Immunogen | Mixture of Human Factor VII and Factor VIIa |
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| Other Names | Blood-coagulation factor VIIa, activated blood coagulation factor VII, formerly known as proconvertin |
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| Gene, Accession # | n/a |
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| Catalog # | HM2347 |
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| Price | |
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| Order / More Info | Coagulation factor VII, Human Antibody from HYCULT BIOTECH |
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| Product Specific References | n/a |
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