产品名称 TNF-alpha, Human Antibody from HYCULT BIOTECH
产品货号 HM2218-FS
产品价格 现货询价,电话:010-67529703
产品规格 0.5 mg
产品品牌 HYCULT BIOTECH
产品概述
产品详情
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Antigenic SpecificityTNF-alpha, Human
Clone5N
Host SpeciesMouse
Reactive Specieshuman, bovine, canine, monkey
IsotypeIgG2a
Formatunconjugated
Size0.5 mg
Concentration500 µg/ml
Applicationsfunctional studies, immunoassay
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DescriptionThe monoclonal antibody 5N reacts with Tumor Necrosis Factor alpha (TNF-alpha). Tumor necrosis factor-alpha (TNF-alpha), a homotrimeric 17 KD protein, is a potent mediator of inflammatory and metabolic functions. TNF-alpha was originally detected as a highly cytotoxic cytokine for tumor cells, it causes tumor necrosis in vivo and shows cytolytic activity against tumor cells in vitro. Further TNF-alpha has been implied as central mediator in shock induced by gram negative micro-organisms. The cytokine TNF-alpha is found to be a central mediator in many inflammatory and immunological processes: it can be induced by various products of micro-organisms and by various cytokines but it also induces on its turn the production of many cytokines. Signal transduction occurs via two types of TNF-receptors, the TNF-receptors I and II. The receptors differ strongly in their intra-cellular signaling pathways. The TNF-alpha trimer interacts with either of the two types of TNF-R leading to receptor cross-linking. The monoclonal antibody 5N cross-reacts and cross-neutralizes all monkey species TNF-alpha, except pig-tail macaque. With affinity about two orders lower it recognizes bovine and canine TNF-alpha.
Immunogenn/a
Other NamesTNF, TNF-SF2, DIF, Cachectin
Gene, Accession #n/a
Catalog #HM2218-FS
Price
Order / More InfoTNF-alpha, Human Antibody from HYCULT BIOTECH
Product Specific Referencesn/a
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