产品名称 TNF-RI, Human Antibody from HYCULT BIOTECH
产品货号 HM2021
产品价格 现货询价,电话:010-67529703
产品规格 50 µg
产品品牌 HYCULT BIOTECH
产品概述
产品详情
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Antigenic SpecificityTNF-RI, Human
CloneH398
Host SpeciesMouse
Reactive Specieshuman, rat
IsotypeIgG2a
Formatbiotin conjugate
Size50 µg
Concentration100 µg/ml
ApplicationsFC, functional studies, immunoassay, IP, WB
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionThe monoclonal antibody H398 recognizes the extracellular part of the Tumor Necrosis Factor Receptor type I (TNF-RI) of the membrane-bound as well as the soluble receptor. TNF-RI (~55-60 kDa) is present on most cell types and is considered to play a prominent role in cell stimulation by TNF-alpha. TNF-alpha activates inflammatory responses, induces apoptosis, regulates cellular proliferation, and may even promote cancer progression. The effects of TNF-alpha are mediated by TNF-RI and TNF-RII, which have both distinct and overlapping downstream signaling cascades. Induction of cytotoxicity and other functions are mediated largely via TNF-RI. TNF-RI is equally well activated by both the 17 kDa soluble and 26 kDa membrane-bound form, whereas TNF-RII is efficiently activated only by the membrane bound form of TNF-alpha. TNF-RI signaling is initiated when trimeric TNF-alpha binds TNF-RI receptors. Subsequent TNF-RI trimerization promotes the recruitment of a proximal signaling complex composed of TNF Receptor Associated protein with a Death Domain (TRADD), Receptor Interacting Protein (RIP), cellular Inhibitor of Apoptosis Protein 1 (cIAP1), TNF Receptor Associated Factor 2 (TRAF2), and likely TRAF5. Studies with TNF-RI-deficient mice indicate that TNF-RI mediates most of the proliferation, pro-inflammatory, and apoptosis-activating pathways.
ImmunogenAffinity-purified receptor material from HL60 cells containing ~9 µg actively binding receptor (Ref.1).
Other NamesCD120a, Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor 1, p55, p60, TNFR-1.
Gene, Accession #TNFRSF1A, TNFAR, TNFR1
Catalog #HM2021
Price
Order / More InfoTNF-RI, Human Antibody from HYCULT BIOTECH
Product Specific Referencesn/a
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