产品名称 TREM-2, Mouse Antibody from HYCULT BIOTECH
产品货号 HM1129F
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 HYCULT BIOTECH
产品概述
产品详情
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Antigenic SpecificityTREM-2, Mouse
Clone6E9
Host SpeciesRat
Reactive Speciesmouse
IsotypeIgG2b
Formatfluorescein (FITC) conjugate
Size100 µg
Concentration100 µg/ml
ApplicationsFC
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DescriptionThe monoclonal antibody 6E9 recognizes mouse membrane-bound as well as soluble triggering receptor expressed on myeloid cells-2 (TREM-2). TREM-2 is a 26 kDa transmembrane glycoprotein that consists of a single extracellular immunoglobulin-like domain, a transmembrane region with a charged lysine residue and a short cytoplasmic tail. It associates with DNAX-activation protein 12 (DAP12) for signaling and function. TREM-2 is expressed on immature monocyte-derived dendritic cells. After activation by microbial products or tumor necrosis factor (TNF) and TNF-related proteins, dendritic cells downregulate the expression of TREM-2. TREM-2 is also expressed by osteoclasts and microglia, where it is involved in bone modeling and brain function, respectively. Another role of TREM-2 might be promoting the removal of apoptotic cells, organic matrix and macromolecules by microglia. Defects in TREM-2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also called presenile dementia with bone cysts or Nasu-Hakola disease (NHD). TREM-2, like TREM-1, can be cleaved on the membrane to release a soluble form of TREM-2 (sTREM-2). Elevated levels of sTREM-2 in CSF of multiple sclerosis patients have been detected. This elevated level may inhibit the anti-inflammatory function of the membrane-bound receptor suggesting sTREM-2 to be a possible target for future therapies.
ImmunogenMouse recombinant TREM-2 protein
Other NamesTriggering receptor expressed on myeloid cells 2, Triggering receptor expressed on monocytes 2, TREM-2.
Gene, Accession #Trem2, Trem2a, Trem2b, Trem2c
Catalog #HM1129F
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Order / More InfoTREM-2, Mouse Antibody from HYCULT BIOTECH
Product Specific Referencesn/a
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