产品名称 Macrophages F4/80, Mouse Antibody from HYCULT BIOTECH
产品货号 HM1066PE-25
产品价格 现货询价,电话:010-67529703
产品规格 25 tests
产品品牌 HYCULT BIOTECH
产品概述
产品详情
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Antigenic SpecificityMacrophages F4/80, Mouse
CloneBM8
Host SpeciesRat
Reactive Speciesmouse
IsotypeIgG2a
Formatphycoerythrin (RPE) conjugate
Size25 tests
Concentrationn/a
Applicationsfrozen sections, FC, paraffin sections, WB
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DescriptionThe monoclonal antibody BM8 recognises a 125 kD extracellular macrophage membrane molecule, highly restricted to mature macrophage subpopulations residing in tissue. This murine F4/80 glycoprotein contains seven-transmembrane (TM7) regions, which anchor the protein in the cell membrane, and thereby shows similarity in this region to G-protein-coupled receptors. The F4/80 molecule shares overall structural homology to other members of the epidermal growth factor (EGF)-TM7 family. The antigen is detected on tissue fixed macrophages in all organs tested so far (spleen, lymph nodes, thymus, liver, skin). It is also present on Langerhans cells in the skin and Kupffer cells in the liver. It is absent on granulocytes, lymphocytes and trombocytes. The expression of F4/80 increases upon maturation of macrophage precursors in bone marrow and blood as well as in ontogeny. The monoclonal antibody BM8 is the only macrophage marker that is able to distinguish non-destructive from destructive inflammation processes in the pancreas. Furthermore it is a unique histological marker of the progression from peri-insulitis to beta-cell destruction and diabetes in a mouse diabetes model. The monoclonal antibody BM8 cross reacts with human heart macrophages.
ImmunogenBALB/c macrophages obtained from 14-day-old bone marrow cell cultures.
Other Namesn/a
Gene, Accession #n/a
Catalog #HM1066PE-25
Price
Order / More InfoMacrophages F4/80, Mouse Antibody from HYCULT BIOTECH
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