产品名称 AC 710 from TOCRIS BIOSCIENCE
产品货号 5013/10
产品价格 现货询价,电话:010-67529703
产品规格 10 mg
产品品牌 TOCRIS BIOSCIENCE
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Product NameAC 710
DescriptionPotent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active. Purity 99%. MW (observed): 562.7
Size10 mg
Concentrationn/a
Applicationsn/a
Other NamesN-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide
Gene, Accession, CAS #CAS: 1351522-04-7
Catalog #5013/10
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Order / More InfoAC 710 from TOCRIS BIOSCIENCE
Product Specific ReferencesPubMed: 29571051
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