| 产品详情 |
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| Product Name | FKGK 18 |
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| Description | An inhibitor of GVIA iPLA2; inhibits GVIA iPLA2 by 99.9% at 0.091 mol fraction in a mixed micelle activity assay; is selective for GVIA iPLA2 over GIVA cPLA2 and GV sPLA2 where it shows 80.8 and 36.8% inhibition, respectively; inhibits iPLA2β activity in cytosolic extracts from INS-1 cells overexpressing iPLA2β (IC50 = ~50 nM) as well as iPLA2γ activity in mouse heart membrane fractions (IC50 = ~1-3 µM); inhibits glucose-induced increases in PGE2 production and insulin secretion in human pancreatic islets at 10 µM; inhibits thapsigargin-induced apoptosis in INS-1 cells overexpressing iPLA2β in a concentration-dependent manner. reduces blood glucose levels in an intraperitoneal glucose tolerance test and incidence of diabetes and increases serum insulin levels in NOD mice at 20 mg/kg, 3 times per week |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | CAS: 1071001-09-6 |
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| Catalog # | 13943-25 |
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| Price | |
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| Order / More Info | FKGK 18 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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