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| Antigenic Specificity | Lamin B1 - Nuclear Envelope Marker |
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| Clone | 119D5-F1 |
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| Host Species | Mouse |
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| Reactive Species | mouse, rat, sheep, rabbit, cow, dog, human, zebrafish |
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| Isotype | IgG1 kappa |
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| Format | purified |
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| Size | 50ul |
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| Concentration | 1mg/ml |
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| Applications | WB, Dot Blot, ELISA, Flow Cyt, ICC/IF, IHC, IP |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Mouse Anti-Lamin B1 [119D5-F1] - Nuclear Envelope Marker. Reacts with an epitope located C-terminal of residue 231 in lamin B1, does not cross react with lamin B2. Lamins do not appear to be universally distributed among different cell and tissue types. It has been shown to react with HeLa and 3T3 cells in immunocytochemistry. Other cell/tissue types have not been tested |
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| Immunogen | Purified rat liver lamins |
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| Other Names | Lamin B1, Lamin B2, LMN, LMN B2, LMN2, LMNB; LMNB1, LMNB2 |
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| Gene, Accession # | n/a |
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| Catalog # | IQ249 |
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| Price | |
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| Order / More Info | Lamin B1 - Nuclear Envelope Marker Antibody from IMMUQUEST LTD. |
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| Product Specific References | Degradation of nuclear matrix and DNA cleavage in apoptotic thymocytes Weaver VM ( J Cell Sci,Jan 1996) PUBMED Ehrnhoefer DE et al. A quantitative method for the specific assessment of caspase-6 activity in cell culture. PLoS One 6:e27680 (2011). WB ; Mouse PUBMED Ciciarello M et al. Nuclear reformation after mitosis requires downregulation of the Ran GTPase effector RanBP1 in mammalian cells. Chromosoma 119:651-68 (2010). ICC/IF ; Mouse PUBMED Kanninen K et al. Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 106:16505-10 (2009) PUBMED Hui RC et al. The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression. Mol Cell Biol 28:5886-98 (2008). WB ; Human PUBMED Thompson J & Winoto A During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain. J Exp Med 205:1029-36 (2008). WB ; Mouse PUBMED Hui RC et al. Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 (MDR1) in K562 leukemic cells. Mol Cancer Ther 7:670-8 (2008). WB ; Human PUBMED Sharma S & Brosh RM Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges. PLoS ONE 2:e1297 (2007). WB ; Human PUBMED Ivorra C et al. A mechanism of AP-1 suppression through interaction of c-Fos with lamin A/C. Genes Dev 20:307-20 (2006) PUBMED Johnson MD et al. Proteome analysis of DNA damage-induced neuronal death using high throughput mass spectrometry. J Biol Chem 279:26685-97 (2004) PUBMED Machiels BM et al. Nuclear lamin expression in normal testis and testicular germ cell tumours of adolescents and adults. J Pathol 182:197-204 (1997) PUBMED Krohne G. Lamins. Methods Cell Biol. 2004;78:573-96WB, ICC/IF, IP. Mouse, HumanPMID: 15646632 |
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