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| Product Name | Recombinant Human IGF-II (carrier-free) |
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| Description | IGF-II is a member of the IGF family, comprised of three members (IGF-I, IGF-II, and insulin). IGF-I and IGF-II share approximately 50% similarity with insulin at the amino acid level. IGF-II is synthesized as a 180 amino acid prepro-IGF-II; pro-IGF-II is processed to its mature, active protein form by glucose regulating protein 94 (GRP94), which possesses chaperone activity towards IGF-II. GRP94 and IGF-II play a key role on muscle differentiation. Seven binding proteins have been described (IGFBP-1 to -7). IGFBPs extend the half life and regulate the availability of the IGFI and IGFII. It has been described that IGFBP3 is the main circulating binding protein for IGFs; in serum, approximately 75% of circulating IGF-I and IGF-II bind to IGFBP3 and the co-carrier acid labile subunit (ALS). IGF-II binds to three receptors, and the binding to IGFIR promotes cell proliferation, survival, differentiation, and migration as well as metabolic function of IGF-II. Embryonic stem cell differentiation into endothelial cells is promoted by the binding of IGF-II to IGFR1. IGF-II binding to IGF-IIR induces internalization and clearing of IGF-II. Osteogenic differentiation and bone formation is enhanced by IGF-II through bone morphogenetic protein-9 (BMP-9). Polymorphisms of IGF-II are associated with obesity, cardiovascular risk factors, and hypertension. |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Insulin-like growth factor II, somatomedin A, IGF-2, IGF2 |
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| Gene, Accession, CAS # | Gene ID: 3481 |
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| Catalog # | 590608 |
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| Order / More Info | Recombinant Human IGF-II (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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