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| Product Name | 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α |
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| Description | A number of 17-aryl trinor and 16-aryloxy tetranor PGF2α derivatives have been approved for the treatment of glaucoma.{8941,9341,8839} These ``ring'' prostaglandin analogs have improved efficacy over the prostaglandins with an n-alkyl lower side chain. Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.{9736} 17-TFM-PGF1α is a typical ``ring'' analog reminiscent of the trifluoromethyl-phenoxy ring of Travoprost. The a chain of 17-TFM-PGF1α is saturated, making this compound a formal member of the one-series PGs. Recent work has shown that in the ``ring'' series of analogs, this modification has little impact on FP receptor binding.{9668} As an ocular hypotensive agent, it is expected that 17-TFM-PGF1α would act very much like the free acid of latanoprost. |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 17-TFM-PGF1α |
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| Gene, Accession, CAS # | CAS: 1027401-98-4 |
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| Catalog # | 15895-5 |
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| Order / More Info | 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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