产品名称 TIM 1/HAVCR1 Antibody from BOSTER BIO
产品货号 PA1632
产品价格 现货询价,电话:010-67529703
产品规格 100ug (sample available)
产品品牌 BOSTER BIO
产品概述
产品详情
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Antigenic SpecificityTIM 1/HAVCR1
Clonepolyclonal
Host SpeciesRabbit
Reactive Speciesrat
Isotypen/a
Formatimmunogen affinity purified
Size100ug (sample available)
Concentration500ug/ml.
ApplicationsIHC, WB
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DescriptionRabbit IgG polyclonal antibody for Hepatitis A virus cellular receptor 1 homolog(HAVCR1) detection. Tested with WB, IHC-P, IHC-F in Rat. No cross reactivity with other proteins. KIM1(KIDNEY INJURY MOLECULE 1), also known as HAVCR1, HAVCR or TIM1, is a protein that in humans is encoded by the KIM1 gene. The KIM1 gene is mapped to 5q33.3. Biochemical, mutational, and cell adhesion analyses confirm that Tim1 is capable of homophilic Tim-Tim interactions. The features identified in murine KIM1 is conserved in human KIM1. The KIM1 protein is indeed a receptor for the virus through the infection of canine osteogenic sarcoma cells expressing HAVCR1 with HAV. Using a monoclonal antibody to mouse Tim1, Tim1 is expressed after activation of naive T cells and on T cells differentiated in Th2-polarizing conditions. Ectopic expression of KIM1 during mouse T-cell differentiation leads to production of the Th2-type cytokine Il4, but not the Th1-type cytokine Ifng. KIM1-expressing epithelial cells internalized apoptotic bodies, and Kim1 is directly responsible for phagocytosis in cultured primary rat tubule epithelial cells and in porcine and canine epithelial cell lines.
ImmunogenA synthetic peptide corresponding to a sequence at the C-terminus of rat TIM 1(289-307aa HPRAEDNIYIIEDRSRGAE).
Other NamesHepatitis A virus cellular receptor 1 homolog;HAVcr-1;Kidney injury molecule 1;KIM-1;T cell immunoglobulin and mucin domain-containing protein 1;TIMD-1;Havcr1;Kim1;
Gene, Accession #HAVCR1, UniProt: O54947
Catalog #PA1632
Price
Order / More InfoTIM 1/HAVCR1 Antibody from BOSTER BIO
Product Specific Referencesn/a
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