| 产品详情 |
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| Product Name | CCT-196969 |
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| Description | Purity ≥98%. MW: 513.5. CCT-196969 is a pan-Raf inhibitor, which inhibits B-Raf, BRafV600E and CRAF with IC50s of 0.1, 0.04, and 0.01 µM, respectively. It is selective for RAFs, Src, LCK, and MAPKs in a panel of 63 kinases when used at a concentration of 1 µM. CCT-196969 inhibits MEK and ERK signaling in B-RAF mutant WM266.4 cells, but not B-RAF wild-type D35 cells, and inhibits growth of B-RAF mutant melanoma cells in a concentration-dependent manner. |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[4-[(3,4-dihydro-3-oxopyrido[2,3-b]pyrazin-8-yl)oxy]-2-fluorophenyl]-N'-[3-(1,1-dimethylethyl)-1-phenyl-1H-pyrazol-5-yl]-urea; CCT196969 |
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| Gene, Accession, CAS # | CAS: 1163719-56-9 |
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| Catalog # | B2500-5 |
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| Price | |
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| Order / More Info | CCT-196969 from BIOVISION, INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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