产品名称 MMP-12/HME Antibody from DENDRITICS SAS
产品货号 DDX0281
产品价格 现货询价,电话:010-67529703
产品规格 100µg/50µg
产品品牌 DENDRITICS SAS
产品概述
产品详情
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Antigenic SpecificityMMP-12/HME
Clone706F9.01
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1
Formatpurified
Size100µg/50µg
Concentrationn/a
ApplicationsELISA capture, IP, WB
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DescriptionProteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes. HME/MMP-12, also called metalloelastase, is reported only in a few cells, including tissue macrophages and hypertrophic chondrocytes. MMP-12 is critical for invasion and destruction in pathologies such as aneurysm and emphysema.The predicted molecular mass of the HME proenzyme is 54 kDa. HME mRNA and protein were detected in human alveolar macrophages. Similar to murine macrophage metalloelastase, HME readily undergoes NH2- and COOH-terminal processing to a mature 22-kDa form. Both recombinant HME expressed in Escherichia coli and native HME derived from human alveolar macrophage-conditioned media degraded insoluble elastin. HME is a unique human metalloproteinase that possesses elastolytic activity and is expressed in alveolar macrophages; MMP-12 mediates smoke-induced inflammation by releasing TNF-alpha from macrophages, with subsequent endothelial activation, neutrophil influx, and proteolytic matrix breakdown caused by neutrophil-derived proteases (Demedts IK et al, Thorax, 61:196-201)
Immunogenn/a
Other NamesProteins of the matrix metalloproteinase
Gene, Accession #n/a
Catalog #DDX0281
Price
Order / More InfoMMP-12/HME Antibody from DENDRITICS SAS
Product Specific Referencesn/a
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