产品名称 TLR3/CD283 Antibody from DENDRITICS SAS
产品货号 DDX0477
产品价格 现货询价,电话:010-67529703
产品规格 100µg/50µg
产品品牌 DENDRITICS SAS
产品概述
产品详情
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Antigenic SpecificityTLR3/CD283
Clone1210F1
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1
Formatpurified
Size100µg/50µg
Concentrationn/a
ApplicationsFlow cytometry, WB, IP, IF
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DescriptionThe Toll-like receptor (TLR) family has recently emerged as key for sensing microbial infections and triggering inflammatory and innate responses. Ten TLRs have been cloned in humans. They share structural and functional homologies, as they are all able to detect micro-organisms through direct recognition of conserved Pathogen Associated Molecular Patterns (PAMPs) such as bacterial lipopolysaccharide (LPS) or viral double stranded RNA (dsRNA). Ligand recognition is mediated through the C-terminal Leucine Rich Repeat region, while signalling involves the N-terminal Toll/Interleukin-1 Receptor (TIR) domain. TLR3 has been identified as a receptor for dsRNA. Unlike other TLRs, the cytoplasmic tail of TLR3 does not contain a conserved proline residue, whose mutation confers LPS unresponsiveness in C3H/HeJ mice. TLR3 is the only TLR that signals exclusively through the TIR?containing adaptor TRIF (TIR?containing adaptor inducing IFNβ), which activates the transcription factors IRF3 and NFκB, and triggers type I interferon secretion. TLR3 is expressed in various cell types, such as fibroblasts, dendritic cells (DCs), or NK cells. While TLR3 is expressed at the cell surface in fibroblasts, it is mostly found in intracytoplasmic vesicles in DCs.
Immunogenn/a
Other NamesToll-like receptor 3
Gene, Accession #n/a
Catalog #DDX0477
Price
Order / More InfoTLR3/CD283 Antibody from DENDRITICS SAS
Product Specific Referencesn/a
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