| 产品详情 |
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| Product Name | WEHI-345 |
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| Description | An inhibitor of RIPK2 (IC50 = 130 nM in a kinase assay using human recombinant RIPK2); selective for RIPK2 over RIPK1, 4, and 5 (Kds = 46, >10,000, >10,000, and >10,000 nM, respectively) and a panel of 95 kinases at a concentration of 1 µM; reduces levels of RIPK2 phosphorylation at Ser176 in MDP-stimulated BMDMs; decreases MDP-induced transcription of TNF and IL-6 in BMDMs and reduces mRNA levels of the NF-κB target genes TNF, IL-8, IL-1β, and A20 in MDP-stimulated THP-1 cells in a concentration-dependent manner; reduces plasma levels of TNF and delays disease onset in a mouse model of EAE when administered at doses ranging from 3-10 mg/kg |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | WEHI345 RIPK-2 1 ser 176 IL8 IL1β NFκB THP1 A 20 interleukin |
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| Gene, Accession, CAS # | CAS: 1354825-58-3 |
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| Catalog # | 23023-5 |
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| Price | |
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| Order / More Info | WEHI-345 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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