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| Product Name | 96-Well ROCK Activity Assay Kit |
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| Description | Background: Members of the Rho family are essential regulatory components of the signaling pathway that direct cell motility, adhesion, and cytokinesis through reorganization of actin cytoskeleton. Rho is activated by extracellular signals such as lysophosphatidic acid (LPA). The actions of Rho are mediated by downstream Rho effectors. One of these effectors is Rho-associated kinase (ROCK). Two ROCK isoforms have been identified: ROCK-I (also known as ROKbeta) and ROCK-II (also known as Rho Kina |
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| Size | 96 assays, 480 assays, |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | MBS168354 |
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| Order / More Info | 96-Well ROCK Activity Assay Kit from MYBIOSOURCE INC. |
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| Product Specific References | 1. Etienne-Manneville, S., and Hall, A. (2002) Nature 420, 629-635.2. Riento, K., and Ridley, A. J. (2003) Nat. Rev. Mol. Cell. Biol. 4, 446-456.3. Leung, T., Manser, E., Tan, L., and Lim, L. (1995) J. Biol. Chem. 270, 29051-29054.4. Matsui, T., Amano, M., Yamamoto, T., Chihara, K., Nakafuku, M., Ito, M., Nakano, T., Okawa, K., Iwamatsu, A., and Kaibuchi, K. (1996) EMBO J. 15, 2208-2216.5. Totsukawa, G, et al., J. Cell Biol. (1999) 144, 735-744.1. Weber, M et al. (2014). MiRNA-155 targets myosin light chain kinase and modulates actin cytoskeleton organization in endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 306:H1192-H1203.2. Narimatsu, T. et al. (2013). Disruption of Cell-Cell Junctions and Induction of Pathological Cytokines in the Retinal Pigment Epithelium of Light-Exposed Mice. Invest. Opthalmol. Vis. Sci. 54:4555-4562.3. Singh, J. et al. (2013). Role of PKC and RhoA/ROCK Pathways in the Spontaneous Phasic Activity in the Rectal Smooth Muscle. Am J Physiol Gastrointest Liver Physiol. 304:G723-G731.4. Barcia, C. et al. (2012). ROCK/Cdc42-Mediated Microglial Motility and Gliapse Formation Lead to Phagocytosis of Degenerating Dopaminergic Neurons in vivo. Sci Rep. 2:809.5. Zhang, W. et al. (2012). The Small GTPase RhoA Regulates the Contraction of Smooth Muscle Tissues by Catalyzing the Assembly of Cytoskeletal Signaling Complexes at Membrane Adhesion Sites. J. Biol. Chem. 287: 33966-34008.6. Burger, D. et al. (2012). Microparticles Induce Cell Cycle Arrest Through Redox-Sensitive Processes in Endothelial Cells: Implications in Vascular Senescence. JAHA. 1: e001842.7. DiPaolo, B.C. et al. (2012). Rho Kinase Signaling Pathways During Stretch in Primary Alveolar Epithelia. Am J Lung Cell Mol Physiol. 302: L992-L1002.8. Burger, D. et al. (2011). Endothelial Microparticle Formation by Angiotensin II is Mediated via Ang II Receptor Type I/NADPH Oxidase/Rho Kinase Pathways Targeted to Lipid Rafts. Arterioscler Thromb Vasc Biol. 31:1898-1907.9. Yotova, I.Y. et al. (2011). Abnormal Activation of Ras/Raf/MAPK and RhoA/ROCKII Signaling Pathways in Eutopic Endometrial Stromal cells of Patients with Endometriosis. Hum. Reprod. 10.1093/humrep/der010.10. Haas, B. et al. (2009). Protein Kinase G Controls Brown Fat Cell Differentiation and Mitochondrial Biogenesis. Sci. Signal. 2:ra78. |
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