产品名称 AL 8810 from CAYMAN CHEMICAL COMPANY
产品货号 16735-10
产品价格 现货询价,电话:010-67529703
产品规格 10 mg
产品品牌 CAYMAN CHEMICAL COMPANY
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Product NameAL 8810
DescriptionAL 8810 is an 11β-fluoro analog of PGF2α which acts as a potent and selective antagonist at the FP receptor.{7398} AL 8810 has weak intrinsic agonist activity on FP receptor preparations in the 200-300 nM range, yet it fully antagonizes the activity of the potent FP receptor agonist fluprostenol at this concentration, with EC50 values of approximately 430 nM. AL 8810 fully antagonized the bimatoprost-induced calcium mobilization in Swiss 3T3 fibroblasts at 100 µM, indicating that bimatoprost acts as an FP agonist in this preparation.{9581} The Ki for the inhibition of several potent agonists at the cloned human ciliary body FP receptor is in the range of 1-2 µM.{10426}
Size10 mg
Concentrationn/a
Applicationsn/a
Other NamesFP antagonists prostaglandins PGFs receptors AL8810 AL-8810 PGF2alpha PGF2.alpha. analogs
Gene, Accession, CAS #CAS: 246246-19-5
Catalog #16735-10
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Order / More InfoAL 8810 from CAYMAN CHEMICAL COMPANY
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