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Product Name | STIMA-1 |
Description | STIMA-1 (SH group-targeting compound that induces massive apoptosis) reactivates mutant p53. STIMA-1 can stimulate mutant p53 DNA binding in vitro and induce expression of p53 target proteins and trigger apoptosis in mutant p53-expressing human tumor cells. STIMA-1 is shown to covalently modify free thiols on mutant p53 in H1299-His175 cells and fully restore its DNA binding activity to the level seen with wild-type p53, resulting in upregulation of p53-dependent gene expression, including p21, PUMA, and Bax. MW: 172.19. Purity ≥97% |
Size | 10 mg |
Concentration | n/a |
Applications | n/a |
Other Names | 2-Vinyl-4H-quinazolinol; SH group-targeting compound that induces massive apoptosis |
Gene, Accession, CAS # | CAS: 91634-12-7 |
Catalog # | 9437-10 |
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Order / More Info | STIMA-1 from BIOVISION, INC. |
Product Specific References | n/a |
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