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| Product Name | Recombinant Rat IL-6 (carrier-free) |
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| Description | IL-6 is a multifunctional cytokine that can regulate various immune and inflammatory responses. IL-6 was initially identified as a B-cell differentiation factor, capable of inducing the maturation of B cells into antibody-producing cells. IL-6 is the major circulating pyrogen during inflammation or injury. Several studies suggested a crucial role for IL-6 in angiogenesis. The use of mice deficient in IL-6 (–/–) demonstrated a critical role for this protein in a mouse model of lung angiogenesis. IL-6 has been shown to cause the proliferation and migration of systemic endothelial cells in culture. The classical responsiveness to IL-6 is governed by a receptor complex consisting of two membrane-bound subunits, an 80 kD cognate-chain (IL-6R), and a ubiquitously expressed 130 kD β-chain receptor (gp130), which acts as the universal signal-transducing element for all IL-6 family cytokines. Alternatively, IL-6 regulation of leukocyte trafficking relies upon the signaling via its soluble IL-6R (termed IL-6 trans-signaling). IL-6 plays a major role in regulating neutrophil clearance during acute peritoneal inflammation as a result of specific down-regulation of neutrophil-attracting chemokine (CXCL1/KC) production. IL-6 is a key factor that reciprocally regulates Th17 and FOXP3(+) Treg differentiation by the inhibition of TGF-β induced FOXP3 and induction of RORγt, which is a Th17 lineage-specific transcription factor. |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Interleukin-6, Interferon-β2, B cell stimulating factor-2 (BSF-2), Cytotoxic T cell differentiation factor (CDF), Hepatocyte stimulating factor (HSF), Hybridoma/plasmacytoma growth factor (HPGF) |
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| Gene, Accession, CAS # | Gene ID: 24498 |
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| Catalog # | 760004 |
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| Price | |
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| Order / More Info | Recombinant Rat IL-6 (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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