| 产品详情 |
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| Product Name | Recombinant Rat IL-5 (carrier-free) |
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| Description | IL-5 is a homodimeric glycoprotein that was initially identified by its ability to support the in vitro growth and differentiation of mouse B cells and eosinophils. IL-5 induces eosinophil progenitor cell proliferation, terminal differentiation, and activation. In animal models of allergic diseases or helminth infection, IL-5 induces a massive proliferation of eosinophil progenitors in the bone marrow, promotes eosinophil recruitment with eotaxins, and prolongs eosinophil survival in local tissues. IL-5 regulates genes involved in B cell terminal differentiation. Thus, IL-5 induces CD38-activated splenic B cells to differentiate into immunoglobulin M-secreting cells and go through m to g1 class switch recombination at the DNA level, resulting in immunoglobulin G1 (IgG1) production. IL-5 binds the IL-5R complex, which consists of an IL-5Rα chain specific for IL-5 and a common β-chain that is shared by the receptors for IL-3 and GM-CSF. The alpha subunit is required for ligand-specific binding whereas association with the beta subunit results in increased binding affinity. IL-5 plays important roles in the pathogenesis of asthma, hypereosinophilic syndromes, and eosinophil-dependent inflammatory disease. |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Interleukin 5, Eosinophil Differentiation Factor (EDF), T-Cell Replacing Factor (TRF), Colony-Stimulating Factor (Eosinophil), B-Cell Differentiation Factor II (BCGF-II), Cytotoxic T-lymphocyte inducer |
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| Gene, Accession, CAS # | Gene ID: 24497 |
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| Catalog # | 778508 |
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| Order / More Info | Recombinant Rat IL-5 (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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