产品名称 PUMA Antibody from INVITROGEN ANTIBODIES
产品货号 PA1-16861
产品价格 现货询价,电话:010-67529703
产品规格 100 µL
产品品牌 INVITROGEN ANTIBODIES
产品概述
产品详情
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Antigenic SpecificityPUMA
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formatpurified
Size100 µL
Concentrationn/a
ApplicationsImmunocytochemistry: 1:20-1:100, Immunofluorescence: 1:20-1:100, Western Blot: 2-4 µg/mL
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DescriptionPUMA Polyclonal Antibody. PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.
Immunogenn/a
Other Namesp53 Upregulated Modulator of Apoptosis, Bcl-2 binding component 3, JFY-1
Gene, Accession #Entrez: 27113; Uniprot: Q96PG8
Catalog #PA1-16861
Price
Order / More InfoPUMA Antibody from INVITROGEN ANTIBODIES
Product Specific Referencesn/a
产品资料