| 产品详情 |
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| Antigenic Specificity | PUMA |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: Assay-dependent, Immunofluorescence: Assay-dependent, Western Blot: 1-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PUMA Polyclonal Antibody. PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway. |
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| Immunogen | n/a |
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| Other Names | p53 Upregulated Modulator of Apoptosis, Bcl-2 binding component 3, JFY-1 |
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| Gene, Accession # | Entrez: 170770, 27113; Uniprot: Q96PG8, Q99ML1 |
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| Catalog # | PA1-30829 |
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| Price | |
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| Order / More Info | PUMA Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 20640889 |
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