| 产品详情 |
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| Product Name | EI1 |
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| Description | EI1 is a potent EZH2 inhibitor that has activity against both wild-type and Y641F mutant EZH2 (IC50s = 15 and 13 nM, respectively). It displays 90-fold selectivity for EZH2 over EZH1 and >10,000-fold selectivity over other lysine methyltransferases. EI1 blocks cellular H3K27 methylation and activates PRC2-specific gene expression. Inhibition of EZH2 by EI1 in diffused large B cell lymphoma cells carrying Y641 mutations results in decreased proliferation, cell cycle arrest, and apoptosis. MW: 390.5. Purity ≥98% by HPLC |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-ethylpropyl)-1H-indole-4-carboxamide |
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| Gene, Accession, CAS # | CAS: 1418308-27-6 |
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| Catalog # | B2270-25 |
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| Price | |
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| Order / More Info | EI1 from BIOVISION, INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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