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| Product Name | Recombinant Human LXR beta-BDL |
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| Description | Human recombinant protein expressed in Nicotiana benthamiana. It is produced by transient expression in non-transgenic plants. This product contains no animal-derived components or impurities. Animal Free product. Liver X Receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids. There are two subtypes, LXRalpha and LXRbeta. The LXRs are ligand-dependent transcription factors that form permissive heterodimers with the retinoid X receptor (RXR). LXR-member of Nuclear Receptor Family is activated by certain oxysterol derivatives of cholesterol. They play an important role in cholesterol, lipid, and carbohydrate metabolism and are critical for the control of lipid homeostasis. LXRalpha is highly expressed in liver tissue. They respond to elevated cholesterol levels via transactivation of genes involved in sterol transport (ABCA1, ABCG1, ABCG5, and ABCG8), cholesterol efflux and high-density lipoprotein (HDL) metabolism, and sterol catabolism (CYP7A1). They also play a central role in regulating cellular lipid content through activation of SREBP-1c, which is the master regulator of de novo lipogenesis. LXRs were found to upregulate angiopoietin- like protein 3 (Angpf13), a member of the family of vascular endothelial growth factors that is also a key regulator of lipid metabolism. LXRs serve as cholesterol sensors that regulate the expression of multiple genes involved in the efflux, transport, and excretion of cholesterol. Synthetic LXR agonists inhibit the development of atherosclerosis in murine models. These observations identify the LXR pathway as a potential target for therapeutic intervention in human cardiovascular disease. Recombinant human LXR beta- LBD is a protein composed of 31.9 kDa (201-461 amino acids). Purity >97% by SDS-PAGE gel |
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| Size | 1 µg, 5 µg, 10 µg, 25 µg |
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| Concentration | n/a |
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| Applications | SDS-PAGE, Western Blot, Antibody Production. Recombinant Human Liver X receptor beta- LBD is applied in protein-protein interaction assays. |
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| Other Names | NR1H2; Liver X receptor beta |
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| Gene, Accession, CAS # | UniProt: P55055 |
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| Catalog # | RF0019 |
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| Order / More Info | Recombinant Human LXR beta-BDL from AGRENVEC |
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| Product Specific References | -Toresson G., Schuster G.U., Steffensen K.R., Bengtsson M., Ljunggren J., Dahlman-Wright K., Gustafsson J.A. 2004. Purification of functional full-length liver X receptor beta produced in Escherichia coli. Protein Expr. Purif. 35(2):190-8. -Quinet E.M., Savio D.A., Halpern A.R., Chen L., Schuster G.U., Gustafsson J.A., Basso M.D., Nambi P. 2006. Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting Mol. Pharmacol. 70(4):1340-9. -Patel M. B., Oza N. A., Anand I. S., Deshpande S. S., Patel C. N. 2008. Liver X Receptor: A Novel Therapeutic Target. Indian J Pharm Sci.; 70(2): 135-144. |
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