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| Product Name | Recombinant Human Neurturin (carrier-free) |
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| Description | Neurturin belongs to the GDNF family of ligands, which consists of 4 members: GDNF, Neurturin, Artemin, and Persephin. GDNF family members orchestrate multiple aspects of the development and maintenance of the central and peripheral nervous systems. These GDNF family ligands signal through a multicomponent receptor system composed of a common signaling component RET (receptor tyrosine kinase) and one of the high affinity binding coreceptor GFRα (α1-α4). Neurturin is a GDNF family member that functions as a ligand for the GFRα2 and RET complex. Neurturin is a potent neurotrophic factor that can promote the survival of numerous neuronal populations, which include the sympathetic, nodose, and dorsal root ganglion sensory neurons. Neurturin is synthesized as a precursor protein that is cleaved to release the carboxy-terminal domain. The carboxy-terminal domain contains seven conserved cysteine residues that are necessary for the formation of the cysteine-knot and the single interchain disulfide bond. The functional form of human Neurturin is a disulfide-linked homodimer of the carboxy-terminal 102 amino acid residues. Studies have shown positive results for Neurturin in protecting and repairing dopaminergic neurons in various models of Parkinson's disease. In association with mutations of RET gene, genetic variations in Neurturin may contribute to Hirschsprung's disease. |
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| Size | 5 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | NRTN, NTN |
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| Gene, Accession, CAS # | Gene ID: 4902 |
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| Catalog # | 760302 |
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| Order / More Info | Recombinant Human Neurturin (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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